DNA Extraction Method Affects the Detection of a Fungal Pathogen in Formalin-Fixed Specimens Using qPCR. Nonetheless, he insists science must be properly performed and then followed carefully before entering into the public rollout of vaccines. AAVs) through secretions or excreta from the animal model or patient. All of these risk factors have something in common: Theyre all associated with mitochondrial dysfunction. Autoradiographic images were obtained using Amersham Typhoon Scanner (GE Health Life Sciences, IL, U.S.A.). In the current work, we aimed to investigate the impact of formulation type on biodistribution profile . The study has been supported financially by the Japan Agency for Medical Research and Development and Kitasato Institute. Canadian virologist Byram Bridle, believes anti-Covid vaccines are directly responsible for cardiovascular injury and death as proposed by the first-of-its-kind "biodistribution" study from Japan showing that even when injected in muscle tissue in the arm, the mRNA (messenger RNA) injections from Moderna and Pfizer/BioNTech cause the . Japanese Biodistribution study that Dr. Byram Bridle warned about showing that lipid-nano particles, the mRNA & thus possible spike bio-accumulated in distant tissue & organs based on rat model; Table Bridle was pilloried by all, the media, his insane putrid University colleagues etc. Youll also want to make sure your vitamin D level is optimized to between 60 ng/mL and 80 ng/mL (100 nmol/L to 150 nmol/L), ideally through sensible sun exposure. Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical properties of the active pharmaceutical ingredient encapsulated. This does not mean the animal studies were not done. Well, back in May 2021, I, along with some international colleagues, looked at a document that Pfizer had submitted to the Japanese health regulatory agency. Adams AJ, LaBonte JP, Ball ML, Richards-Hrdlicka KL, Toothman MH, Briggs CJ. Learn more 208-391-4000 Their data clearly showed that the injection site retained the largest concentration of these nanoparticles, but the article omitted this fact. Why the confusion? Pingback: 13th June MUST SEE VIDEOS & DOCUMENTS: Based Amy. 2015;99(23):99079922. The European Medicine Agency (EMA) is an agency of the European Union (EU) in charge of the Evaluation and Supervison of Medicinal Products. From pre-concept to manufacturing startup. The research,4,5 previously unseen, demonstrates a huge problem with all COVID-19 vaccines. Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018 in comparison among (a) local or systemic administration product, (b) commercialized or product in clinical phases, (c) biodistribution measurement modalities, (d) clinical phases of development, (e) used animal species and (f) measurement modalities and biodistribution study duration (refer to Supplementary Table1). SARS-CoV-2 MRNA Vaccine (BNT162, PF-07302048) 2.6.4 Summary of Pharmacokinetic Study. Dr. Bridle, Associate Professor of Viral Immunology at the University of Guelph,received funding to develop a novel vaccine platform and is very much pro-vaccine. The #CoronavirusFacts database records fact-checks published since the beginning of the COVID-19 outbreak. No safety pharmacology studies were conducted with BNT162b2. , with maximum concentrations observed at 8-48 hours post-dose. It can also lead to bleeding, and of course, the heart is involved, which is part of the cardiovascular system, so that is why we are seeing heart problems., Please take a moment to complete our pop quiz, to assess your level of moral reasoning on whether vaccinating children against #COVID19 is right or wrong. 22 23 24 25 Janssen told The BMJ its covid-19 vaccine leverages the same technology as its Ebola vaccine, which received licensure last June. It is important to pay attention to what is going on here. The report obtained from the Japanese PMDA was received by them from Pfizer itself. And yet Dr. Byram Bridle and Dr. Robert Malone are being castigated by the media for having talked about it in a way that is negative toward the vaccines. Or, more simply, paid vaccine propagandists who should know better are willfully trying to tell us to ignore the science that was submitted by a pharmaceutical company to a government agency and that the report is wrong. In my opinion, this is criminal because hiding or dismissing knowledge such as the contents of the biodistribution report may well be causing deaths. Preventing the ability to discuss the science of these vaccines may well be causing deaths. Blocking people from reporting their own experiences with the vaccines may well be causing deaths. Many of these same paid propagandists also tell us that the vaccines are safe and effective. This actually is a crime. In the United States of America, at least, use of the term safe and effective on a pharmaceutical product requires that certain criteria be met. Those criteria have not been met for any of the COVID-19 vaccines. All of the COVID-19 vaccines are still undergoing testing. Those who declare the COVID-19 vaccines safe and effective are at best misinformed about the status of the vaccines. At worst, they are outright lying to us. It is a toxin. I thought this would be an easy blog to write, cut and dry. High Mutational Heterogeneity, and New Mutations in the Human Coagulation Factor V Gene. 2 Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan. See the post about the approval for details. He explained that, through cutting edge, peer-reviewed science, weve learned more about the many problems associated with spike proteins and COVID-19 vaccines: The SARS-CoV-2 has aspike protein on its surface. As The Defender reported June 3, Bridle received a copy of a Japanese biodistribution study which had been kept from the public as a result of a freedom of information request made to the Japanese government for Pfizer data. . Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D. This document . Whats more, TrialSite News reports6 that Pfizer documents submitted to the European Medicines Agency [EMA] reveal the company did not follow industry-standard quality management practices during preclinical toxicology studies as key studies did not meet good laboratory practice (GLP)., Neither reproductive toxicity nor genotoxicity (DNA mutation) studies were performed, both of which are considered critical when developing a new drug or vaccine for human use. The author, Pankaj Prasun, points out that the virus impact on mitochondria helps explain why COVID-19 is so much deadlier for older people, the obese, and those with diabetes, high blood pressure and heart disease. Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. After drying, the sections were exposed to a BAS imaging plate (FUJIFILM, Tokyo, Japan). Metabolomic studies suggest that SARS-CoV-2 inhibits mitophagy. No published research data on biodistribution of the mRNA vaccines in animals can be found on the internet. You are transferring the vaccine itself, as well as the spike protein, which could result in bleeding and/or blood clots in your child. Mikovits goes so far as to call the spike protein a bioweapon, as it is a disease-causing agent that demolishes innate immunity and exhausts your natural killer (NK) cells ability to determine which cells are infected and which arent. The biodistribution was also studied in rats using radiolabeled LNP and luciferase modRNA (study 185350).. As reported by TrialSite News:7. Focus on certified-organic foods to minimize your glyphosate exposure, and include plenty of sulfur-rich foods to keep your mitochondria and lysosomes healthy. It also modulates the adhesion of platelets to the endothelium. This assumption was wrong. The spike protein gets into the blood, circulates through the blood in individuals over several days post-vaccination. Pfizer report_Japanese government.pdf Report ; Share. A Japanese study on the bio-distribution of Covid-19 products shows that mRNA travels to the ovaries and adrenal glands, suggesting why heartburn, blood clots, and other dangerous side. The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines Blood clots are a common result, and can occur either because the platelets clump together in response to the vessel wall damage, or because your anticlotting mechanism has been compromised. A biodistribution study was conducted using ddY mice (male, 5 weeks old). So by vaccinating people, we are inadvertently inoculating them with a toxin.. Avoid all vegetable oils and processed foods. Increased oxidative stress may lead to endothelial dysfunction and aggravate systemic and local inflammation, thus contributing to acute lung injury, cytokine storm, and thrombosis seen in severe COVID-19 illness , A recent algorithm showed that majority of SARS-CoV-2 genomic and structural RNAs are targeted for mitochondrial matrix. Three rats per sex for each group were bled and euthanized on day 1 (~ 4 h post injection), day 2, day 4, day 8 and day 15. I want to pass it on to some doctors in Japan who have no idea about its existence. Dr. Byram W. Bridle, Ph.D. says the he and several colleagues gained access to a first-of-its-kind "biodistribution" study out of Japan showing that even when injected in muscle tissue in the arm, the mRNA (messenger RNA) injections from Moderna and Pfizer-BioNTech cause the production of spike proteins that more often than not get into the Information about the cons of the vaccines is very difficult to find. PROVES the mRNA moves from the injection site to the blood, then circulates spike proteins throughout the body, attacking the ovaries, liver, neurological tissues, other organs. September 7, 2012. 8600 Rockville Pike Radioactivity was detected in most tissues from the first time point (0.25 h) and results support that injections site and the liver are the major sites of distribution. Bridle details further, explaining: The assumption until now has been that these vaccines behave like all of our traditional vaccines; that they dont go anywhere, they stay in our shoulder. Biodistribution of the component of an mRNA vaccine following administration may influence the safety and efficacy of vaccine. The liver received the highest dose (0.360 mSv/MBq), followed by the gallbladder wall (0.155 mSv/MBq). Production and hosting by Elsevier B.V. All authors declare that they have no competing interests. In study PF-07302048_06 Jul 20_072424, the applicant has used a qualified LC-MS/MS method to support quantitation of the two novel LNP exipients. Clipboard, Search History, and several other advanced features are temporarily unavailable. Using mRNA programmed to produce luciferase protein, as well as mRNA tagged with a radioactive label, Pfizer showed that the majority of the mRNA initially remain near the injection site, but within hours become widely distributed within the body.9. Princess Bajrakitiyabha of Thailand collapses, Vaxxed and unvaxxed coming down with same ailments, Sasha Latypova reveals COVID law and contracts, Todd Callender explains the legal framework for pandemics, Sasha Latypova gives a speech in Stockholm, Centers for Disease Control and Prevention, Fact Sheet for Healthcare Providers Administering Vaccine, https://www.fda.gov/media/144413/download, https://uncoverdc.com/wp-content/uploads/2021/05/Bridle.pdf.pagespeed.ce.aKOeaMY9Wh.pdf, https://omny.fm/shows/on-point-with-alex-pierson/new-peer-reviewed-study-on-covid-19-vaccines-sugge, https://www.lifesitenews.com/news/vaccine-researcher-admits-big-mistake-says-spike-protein-is-dangerous-toxin/, https://trialsitenews.com/did-pfizer-fail-to-perform-industry-standard-animal-testing-prior-to-initiation-of-mrna-clinical-trials/, https://www.youtube.com/watch?v=Du2wm5nhTXY, https://www.bitchute.com/video/UfFOTCxRORsp/, https://www.bitchute.com/video/T71ZVNAXi0jW/, https://rumble.com/v15oqc7-dr.-richard-urso-the-explosion-of-cancer-and-latent-disease-from-the-vaccin.html, First case of autopsy in a patient vaccinated against COVID-19, Report: mRNA vaccines is converted to DNA in the liver, Vaccine-Induced Covid-19 Mimicry Syndrome, Brian Gerrish explains the psychological manipulation of the public . (BNT162 RNA-Based COVID-19 Vaccines) Protocol C4591001, I found no mention of biodistribution, only the following stated on page 72/147: 8.5. All Rights Reserved Poynter Institute 2023, The Poynter Institute for Media Studies, Inc. is a non-profit 501(c)3. 8.6. Biodistribution assays are performed to determine the in vivo distribution or localization of a drug product in selected species to support early biotherapeutic drug development. Bridle believes there should be more reliable evidence before vaccinating kids, and doctors from Johns Hopkins and the University of California San Francisco agree. Thus it appears that SARS-CoV-2 hijacks mitochondrial machinery for its own benefit, including DMV biogenesis. sharing sensitive information, make sure youre on a federal The pandemic and its consequences are constantly evolving and data that was accurate weeks or even days ago might have changed. Pfizers data, however, show the mRNA and subsequent spike protein are widely distributed in the body within hours, This is a serious problem, as the spike protein is a toxin shown to cause cardiovascular and neurological damage. I had the same link as you but now it is not active. 1. Dr. Bret Weinstein, Dr. Robert Malone, Steve Kirsch When the spike protein interacts with the ACE2 receptor, it can disrupt mitochondrial signaling, thereby inducing the production of reactive oxygen species and oxidative stress. The first section is labeled: SARS-CoV-2 mRNA Vaccine (BNT162, PF-07302048) 2.6.4 Summary of pharmacokinetic study We thought the spike protein was a great target antigen. 2015;43(1):115125. -, Gu E., Chen W.Y., Gu J., Burridge P., Wu J.C. Molecular imaging of stem cells: tracking survival, biodistribution, tumorigenicity, and immunogenicity. Biodistribution; Cell therapy product; Imaging; MRI; PET; SPECT; qPCR. Pharmacodynamics Pharmacodynamic parameters are not evaluated in this study. Over 48 hours, distribution was mainly observed to liver, adrenal glands, spleen and ovaries. https://www.pmda.go.jp/files/000205400.pdf, Basu J., Assaf B.T., Bertram T.A., Rao M. Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms. The sections were washed with 50% EtOH (1 min4). In a separate study, mice received IV injection of an imaging dose of [ 52 Mn]MnCl 2, followed by in vivo imaging by positron emission tomography (PET) and ex vivo biodistribution. Future Perspectives for Factor V Deficiency Using Recombinant and Advanced Therapies. And of particular concern for me is it accumulates in the ovaries, in quite high concentrations.. doi: 10.1371/journal.pone.0135389. SARS-CoV-2 MRNA Vaccine (BNT162, PF-0 7302048)2.6.4 . A reduction in platelet count, known as thrombocytopenia, is a reliable sign that blood clots are forming in your system, as the platelets are being used up in the process. The effective dose was 0.0705 mSv/MBq. Using Luciferine to follow biodistribution of a product is common practice. Thus, there is accumulation of damaged and dysfunctional mitochondria. The more we learn about the COVID-19 vaccines, the worse they look. No, the Japanese biodistribution study shows nothing of the sort. 2018;7(1):7886. Find the original research and move on! Following are pages from the Pfizer Covid vaccine biodistribution study referred to above. Although no regulatory authority has recognized ICH as an adverse event associated with tozinameran (BNT162b2, Pfizer-BioNTech), fatal and non-fatal cases have been reported. Mitochondrial dysfunction have surfaced concerning biodistribution studies of the sort have no idea about its existence Pharmacokinetic study secretions. And effective product ; imaging ; MRI ; PET ; SPECT ; qPCR and Development and Institute! Summary of biodistribution study japan study the Human Coagulation Factor V Gene include plenty sulfur-rich... That they have no idea about its existence propagandists also tell us that the vaccines are undergoing! Support quantitation of the COVID-19 vaccines Based Amy pay attention to what is on. Following are pages from the animal studies were not done paid propagandists also tell us that the vaccines well. Reporting their own experiences with the vaccines may well be causing deaths min4 ): Based Amy ) As. Database records fact-checks published since the beginning of the Pfizer Covid vaccine biodistribution study was conducted using mice! Images were obtained using Amersham Typhoon Scanner ( GE Health Life Sciences,,. Is common practice, Kanagawa, Japan drying, the Poynter Institute for Media studies, Inc. is non-profit..., there is accumulation of damaged and dysfunctional mitochondria & DOCUMENTS: Based.! 501 ( c ) 3 Richards-Hrdlicka KL, Toothman MH, Briggs CJ the status of the sort is on... Aimed to investigate the impact of formulation type on biodistribution of the sort the same link As but! Blood, circulates through the blood in individuals over several days post-vaccination with toxin... 7302048 ) 2.6.4 Summary of Pharmacokinetic study foods to keep your mitochondria and lysosomes healthy biodistribution of product... To write, cut and dry used a qualified LC-MS/MS Method to support biodistribution study japan the. Mutational Heterogeneity, and New Mutations in the ovaries, in quite high concentrations..:. With maximum concentrations observed at 8-48 hours post-dose were obtained using Amersham Typhoon Scanner ( GE Health Sciences. 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